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Lafutidine - Wikipedia Like other H 2 receptor antagonists, lafutidine acts by preventing the secretion of gastric acid [3] It also activates calcitonin gene-related peptide, resulting in the stimulation of nitric oxide (NO) and regulation of gastric mucosal blood flow, increases somatostatin levels also resulting in less gastric acid secretion, causes the stomach lining to generate more mucin, inhibits neutrophil
Treatment of Intractable Cancer Pain with Resiniferatoxin — An Interim . . . A substantial number of patients with advanced cancer suffer from refractory pain despite comprehensive medical management In this article, we evaluate a nonopioid analgesic, resiniferatoxin (RTX), a potent agonist of the transient receptor potential vanilloid 1 (TRPV1) ion channel, which selectively interrupts nociceptive activity transmitted by a subpopulation of dorsal root ganglion neurons
How Do LAIs Work? - Lifescient Long-acting injectables (LAIs) represent a significant advancement in drug delivery systems, designed to sustain the release of a medication over an extended period, for weeks and days at a time, continuously following a single administration